Sara Jones, Ph.D.
Education Duke University, Postdoctoral Research (1994-1999) University of North Carolina, PhD Neurobiology (1994) University of Georgia, BS/BA Biology and Psychology (1987) Research Area Addiction, cocaine abuse, alcoholism, ritalin, ADHD, methamphetamine neurotoxicity, knockout mice Academic Activities Research Advisory Committee, Faculty Development Advisory Committee, Transgenic Mouse Core Advisory Committee, Primate Center Advisory Committee Medical and Graduate Education Co-Director of Graduate Studies, Director of Advanced Topics in Physiology and Pharmacology (PSPR704), lecturer in various graduate and medical student courses, Standardized Patient Assessment evaluator for medical education Brief Summary of Research Our laboratory is mainly focused on measuring monoamine (dopamine, serotonin and norepinephrine) neurotransmitters in several different animal models of drug and alcohol abuse. The two primary techniques used are cyclic voltammetry and microdialysis. We have current projects examining the consequences of chronic exposure to cocaine, alcohol, methamphetamine, ritalin and speedball. We have ongoning collaborations with Dr. David Roberts concerning the neurobiological consequesces of cocaine self-administration and with Dr. Jeff Weiner concerning the impact of ritalin treatment on alcohol self administration in rats.
Ferris MJ, Mateo Y, Roberts DCS, Jones SR. Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. Biol Psychiatry. 2011; 69(3):201-207. Espana RA, Melchior JR, Roberts DCS, Jones SR. Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration. Psychopharmacology (Berl). 2011; 214(2):415-426. Espana RA, Oleson EB, Locke JL, Brookshire BR, Roberts DCS, Jones SR. The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system. Eur J Neurosci. 2010; 31(2):336-348. Mathews TA, Locke J, Friedman DP, Jones SR. Dopamine and serotonin neurochemistry in long-term alcohol drinking nursery and mother reared monkeys [abstract]. Alcohol Clin Exp Res. 2009; 33(6 Special Issue):23A. Brookshire BR, Jones SR. Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice. Pharmacol Biochem Behav. 2009; 94(1):194-203. Carter ES, Chappell AM, Jones SR, Weiner JL. Effect of oral adolescent methylphenidate treatment and withdrawal on ethanol drinking and locomotor response to psychostimulants [abstract]. Alcohol Clin Exp Res. 2009; 33(6 Special Issue):98A. Mathews TA, Brookshire BR, Budygin EA, Hamre K, Goldowitz D, Jones SR. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol. 2009; 43(6):421-431. Oleson EB, Salek J, Bonin KD, Jones SR, Budygin EA. Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice. Neurosci Lett. 2009; 467(2):144-146. Lack CM, Jones SR, Roberts DCS. Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats. Psychopharmacology (Berl). 2008; 195(4):517-525. Mathews TA, Brookshire BR, Budygin EA, Daunais JB, Friedman DP, Jones SR. A neurochemical comparison of striatal dopamine function in drinking monkeys [abstract]. Alcohol Clin Exp Res. 2008; 32(6 Suppl 1):35A. Chappell AM, Jones SR, Weiner JL. Effect of adolescent methylphenidate treatment on ethanol self-administration in male Long-Evans rats [abstract]. Alcohol Clin Exp Res. 2008; 32(6 Suppl 1):220A. Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, Akbarian S. Drug-induced activation of dopamine D-1 receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology. 2008; 33(12):2981-2992. Espana RA, Roberts DCS, Jones SR. Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery. Neuroscience. 2008; 155(1):250-257. Mathews TA, Locke J, Jones SR. Chronic ethanol vapor exposure downregulates presynaptic dopamine function in the nucleus accumbens of mice [abstract]. Alcohol Clin Exp Res. 2008; 32(6 Suppl 1):157A. John CE, Jones SR. Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007; 52(8):1596-1605. Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007; 193(4):495-501. Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz M, McCool BA, Jones SR. Terminal effects of chronic alcohol exposure on dopamine dynamics in rat striatum [abstract]. Alcohol Clin Exp Res. 2007; 31(6 Suppl):83A. John CE, Jones SR. Fast scan cyclic voltammetry of dopamine and serotonin in mouse brain slices. In: Michael AC, Borland LM, eds. Electrochemical methods for neuroscience. Boca Raton (FL): CRC Press; 2007: 49-62. John CE, Jones SR. Exocytotic release of dopamine in ventral tegmental area slices from C57BL/6 and dopamine transporter knockout mice. Neurochem Int. 2006; 49(8):737-745. Mathews TA, John CE, Lapa GB, Budygin EA, Jones SR. No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse. 2006; 60(4):288-294. Brookshire BR, Lapa A, Mathews TA, Jones SR. Cocaine and ethanol effects on nucleus accumbens dopamine in 22-TNJ mutant mice [abstract]. Alcohol Clin Exp Res. 2006; 30(6 Suppl):181A. Nordskog BK, Alexander GM, Hammarback JA, Mathews TA, Jones SR, Fisher TL, Godwin DW. Alterations in the molecular physiology of T-type calcium channels during ethanol withdrawal [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer):. John CE, Budygin EA, Weiner JL, Jones SR. NMDA receptor deficient mice display altered synaptic function and reward related behaviors [abstract]. Neuropsychopharmacology. 2006; 31(Suppl):S76. Budygin EA, Jones SR. Accumbal dopamine release, but not uptake or synthesis, is altered by low and moderate doses of acute ethanol [abstract]. Alcohol Clin Exp Res. 2006; 30(6 Suppl):182A.