Robert C. Coghill

Neuroscience PhD at Wake Forest University at Wake Forest University

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Robert C. Coghill

Robert C. Coghill
  • E-mail:
  • Department: Neurobiology/Anatomy
  • Phone Number: (336) 716-4284
  • Research Interests: Neurosciences/Behavior, Pain, Radiology/Imaging

RESEARCH OVERVIEW

The capacity to monitor the integrity of our bodies and to be made immediately aware of injury through the experience of pain is critical for our survival. However, the central nervous system mechanisms that translate information about tissue damage into the conscious experience of pain remain poorly understood. Thus, the central objective of my laboratory’s research is to better characterize fundamental aspects of pain processing mechanisms of the brain. Most studies within my laboratory employ both psychophysical and functional magnetic resonance imaging (fMRI) techniques to explore the relationship between regional brain activation and discrete aspects of the pain experience.

 

SELECTED PUBLICATIONS

  • Mørch CD, Andersen OK, Quevedo AS, Arendt-Nielsen L, Coghill RC. Exteroceptive aspects of nociception: insights from graphesthesia and two-point discrimination. Pain. 2010 Oct;151(1):45-52.
  • Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting discrimination of sensory features of pain: a new model. J Neurosci. 2009 Nov 25;29(47):14924-31.
  • Yelle MD, Oshiro Y, Kraft RA, Coghill RC. Temporal filtering of nociceptive information by dynamic activation of endogenous pain modulatory systems. J Neurosci. 2009 Aug 19;29(33):10264-71.
  • Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, Coghill RC. Roles of the insular cortex in the modulation of pain: insights from brain lesions. J Neurosci. 2009 Mar 4;29(9):2684-94.
  • Quevedo AS, Coghill RC. Attentional modulation of spatial integration of pain: evidence for dynamic spatial tuning. J Neurosci. 2007 Oct 24;27(43):11635-40.
  • Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting spatial discrimination of pain. J Neurosci. 2007 Mar 28;27(13):3388-94.
  • Koyama T, McHaffie JG, Laurienti PJ, Coghill RC. The subjective experience of pain: where expectations become reality. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12950-5.
  • Coghill RC, McHaffie JG, Yen YF. Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8538-42.
  • Grill JD, Coghill RC. Transient analgesia evoked by noxious stimulus offset. J Neurophysiol. 2002 Apr;87(4):2205-8.
  • Coghill RC, Gilron I, Iadarola MJ. Hemispheric lateralization of somatosensory processing. J Neurophysiol. 2001 Jun;85(6):2602-12.
  • Coghill RC, Sang CN, Maisog JM, Iadarola MJ. Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol. 1999 Oct;82(4):1934-43.
  • Iadarola MJ, Max MB, Berman KF, Byas-Smith MG, Coghill RC, Gracely RH, Bennett GJ. Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain. Pain. 1995 Oct;63(1):55-64.
  • Coghill RC, Talbot JD, Evans AC, Meyer E, Gjedde A, Bushnell MC, Duncan GH. Distributed processing of pain and vibration by the human brain. J Neurosci. 1994 Jul;14(7):4095-108.