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Neuroscience PhD at Wake Forest University at Wake Forest University

Wake Forest University Graduate School » Neuroscience PhD at Wake Forest University

Paul Laurienti

Paul Laurienti
I direct the Laboratory for Complex Brain Networks (LCBN) that includes multiple faculty, students and staff. Our research evaluates the human brain as a complex system using network science methods. These studies use whole-brain connectivity to identify critical network nodes, network neighborhoods, and dynamic changes that occur under various cognitive states. Network science is proving to be a powerful tool for assessing brain structure and function and our laboratory is currently evaluating how dynamic changes in network connectivity may be critical for multisensory integration. Furthermore, we are evaluating age-related changes in brain connectivity with the hypothesis that cognitive decline in older adults may be better explained by global changes in network connectivity rather than by alterations in focal brain areas.


Please see our laboratory website.


Telesford QK, Morgan AR, Hayasaka S, Simpson SL, Barret W, Kraft RA, Mozolic JL, Laurienti PJ. Reproducibility of graph metrics in fMRI networks. Front. Neuroinform. 2010; 4:117. Available online  
Presley TD, Morgan AR, Bechtold E, Clodfelter W, Dove RW, Jennings JM, Kraft RA, King SB, Laurienti PJ, Rejeski WJ, Burdette JH, Kim-Shapiro DB, Miller GD. Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide: Biology and Chemistry 2011; 24(1): 34-42. Available online  Joyce KE, Laurienti PJ, Burdette JH, Hayasaka S. A New Measure of Centrality for Brain Networks. PLoS ONE 5(8): e12200 (2010) Available online    Burdette JH, Laurienti PJ, Espeland MA, Morgan A, Telesford Q, Vechlekar CD, Hayasaka S, Jennings JM, Katula JA, Kraft RA, Rejeski WJ. Using network science to evaluate exercise-associated brain changes in older adults. Frontiers in Aging Neuroscience, 2: 23 (2010) Available online   Hayasaka S, Laurienti PJ. Comparison of Characteristics between Region- and Voxel-Based Network Analysis in Resting-State fMRI. NeuroImage, 50: 499-508 (2010) Manuscript [PDF 1.0MB]   Hugenschmidt CE, Hayasaka S, Peiffer AM, Laurienti PJ. Applying capacity analyses to psychophysical evaluation of multisensory interactions. Information Fusion 2010; 11(1): 12-20. Available Online  Mozolic JL, Hayaska S, Laurienti PJ. A cognitive training intervention increases resting cerebral blood flow in healthy older adults. Front. Hum. Neurosci. 2010; 4:16. Available Online Stein BE, Burr D, Constantinidis C, Laurienti PJ, Alex Meredith M, Perrault TJ Jr, Ramachandran R, Roder B, Rowland BA, Sathian K, Schroeder CE, Shams L, Stanford TR, Wallace MT, Yu L, Lewkowicz DJ. Semantic confusion regarding the development of multisensory integration: a practical solution. Eur J Neurosci. 2010; 31(10): 1713-1720. Available Online Peiffer AM, Hugenschmidt CE, Laurienti PJ. Ethics in 15 min per Week. Sci Eng Ethics. 2010. Available Online
Addicott MA, Laurienti PJ. A comparison of the effects of caffeine following abstinence and normal caffeine use. Psychopharmacology, 207: 423-31 (2009)
 Addicott MA, Yang LL, Peiffer AM, Burnett LR, Burdette JH, Chen MY, Hayasaka S, Kraft RA, Maldjian JA, Laurienti PJ. The effect of daily caffeine use on cerebral blood flow: how much caffeine can we tolerate? Human Brain Mapping, 30: 3102-14 (2009) Addicott MA, Yang LL, Peiffer AM, Laurienti PJ. Methodological considerations for the quantification of self-reported caffeine use. Psychopharmacology, 203: 571-8 (2009) Hugenschmidt CE, Mozolic JL, Tan H, Kraft RA, Laurienti PJ. Age-Related Increase in Cross-Sensory Noise in Resting and Steady-State Cerebral Perfusion. Brain Topogr., 21: 241-52 (2009) Hugenschmidt CE, Peiffer AM, McCoy TP, Hayasaka S, Laurienti PJ. Preservation of crossmodal selective attention in healthy aging. Exp Brain Res, 198: 273-85 (2009) Hugenschmidt CE, Mozolic JL, Laurienti PJ. Suppression of multisensory integration by modality-specific attention in aging. Neuroreport, 20: 349-53 (2009) Mozolic JL, Long AB, Morgan AR, Rawley-Payne M, Laurienti PJ. A cognitive training intervention improves modality-specific attention in a randomized controlled trial of healthy older adults. Neurobiol Aging, in press. (2009) Peiffer AM, Hugenschmidt CE, Maldjian JA, Casanova R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ. Aging and the interaction of sensory cortical function and structure. Human Brain Mapping 30(1): 228-240. (2009)