Structural and functional alterations in the neuromuscular system lead to physical disability and loss of independence in the elderly. Despite the importance of muscle strength in preventing physical disability, the cellular and molecular mechanisms responsible for the age-dependent decline in the neuromuscular system are only partially understood. The main focus of our research is to determine the molecular and cellular mechanisms underlying the age-dependent alterations in structure and function of motor neurons and skeletal muscle fibers. Particularly, we are interested in the reciprocal interaction between muscle cells and brain and spinal cord motor neurons, the mutual influence of neurons and muscle cells on gene expression, the role of trophic factors and ion channels in tissue function, and interventions aimed at ameliorating and/or delaying the age-dependent impairment in the neuromuscular system.
Coming soon . .
Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER. Pflugers Arch. 2010; 459(5):725-735.
Delbono O. Myosin–still a good reference for skeletal muscle fibre classification? [editorial comment]. J Physiol. 2010; 588(Pt 1):9.
Loeser RF Jr, Delbono O. Aging of the muscles and joints. In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, Hazzard WR, Wollard NF, eds. Hazzard’s geriatric medicine and gerontology. 6th ed. New York: McGraw Hill Medical; 2009: 1355-1368.
Payne AM, Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging. Exp Gerontol. 2009; 44(4):261-273.
Zorzato F, Delbono O, Treves S, Nishi M, Takeshima H. Modulation of skeletal muscle excitation-contraction coupling by protein components of the sarcoplasmic reticulum junctional face membrane [abstract]. J Physiol Sci. 2009; 59(Suppl 1):42.
Taylor JR, Zheng Z, Wang ZM, Payne AM, Messi ML, Delbono O. Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness. Aging Cell. 2009; 8(5):584-594.
Yoshikawa M, Vinsant S, Mansfield CM, Gifondorwa DJ, Pace L, Messi LM [sic] [Messi ML], Caress J, Cartwright M, Delbono O, Oppenheim RW, Milligan CE, et al. Identification of changes in muscle, neuromuscular junctions and spinal cord at early pre-symptomatic stages in the mutant SOD1 mouse model of ALS may provide novel insight for diagnosis and treatment development [abstract]. Soc Neurosci Abstr. 2009; 2009(Neuroscience Meeting Planner):.
Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O’Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008; 20(4):302-309.
Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Failure to generate action potential in aging muscle fibers under physiological recording conditions [abstract]. Biophys J. 2008; (Suppl):310.
Jimenez-Moreno R, Wang Z-M, Gerring RC Delbono O. Sarcoplasmic reticulum Ca2+ release declines in muscle fibers from aging mice. Biophys J. 2008; 94(8):3178-3188.
Jimenez-Moreno R, Zheng ZL, Delbono O. Sareoplasmic/endoplasmic reticulum Ca2+ content and release analyzed with the genetically targeted chameleon Ca2+ indicators D1ER and D4ER [abstract]. Biophys J. 2007; (Suppl):255a.
Wang ZM, Zheng Z, Messi ML, Delbono O. Muscle fibers from senescent mice retain excitation-contraction coupling properties in culture. In Vitro Cell Dev Biol Anim. 2007; 43(7):222-234.
Delbono O, Xia J, Treves S, Wang Z-M, Jimenez-Moreno R, Payne AM, Messi ML, Briguet A, Schaerer F, Nishi M, et al. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Proc Natl Acad Sci U S A. 2007; 104(50):20108-113.
Payne AM, Messi ML, Zheng ZL, Delbono O. Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice [abstract]. Biophys J. 2007; (Suppl):310a.
Zheng Z, Wang Z-m, Payne AM, Jimenez-Moreno R, Delbono O. DHPR beta1a subunit expression increases in aging skeletal muscle [abstract]. Biophys J. 2007; (Suppl):311a.
Messi ML, Clark HM, Prevette DM, Oppenheim RW, Delbono O. The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS. Exp Neurol. 2007; 207(1):52-63.
Payne AM, Messi ML, Zheng Z, Delbono O. Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice. Exp Gerontol. 2007; 42(4):309-319.
Zorzato F, Xia J, Treves S, Jimenez-Moreno R, Wang Z-M, Payne AM, Messi ML, Briguet A, Schaerer F, Delbono O, et al. Knockout of the gene encoding the sareoplasmic reticuhum protein JP-45 impairs excitation-contraction coupling in skeletal muscle [abstract]. Biophys J. 2007; (Suppl):21a.
Moreno RJ, Messi ML, Zheng Z, Wang Z-M, Ye P, D’Ercole JA, Delbono O. Role of sustained overexpression of central nervous system IGF-I in the age-dependent decline of mouse excitation-contraction coupling. J Membr Biol. 2006; 212(3):147-161.