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Neuroscience PhD at Wake Forest University at Wake Forest University


Wake Forest University Graduate School » Neuroscience PhD at Wake Forest University

Michael Nader, Ph.D.

Michael Nader, Ph.D.
The research conducted in this laboratory is aimed at understanding the neuropharmacology of cocaine abuse with the goal of identifying novel treatment strategies. To accomplish this goal, we utilize schedule-controlled behavior, cocaine self-administration, drug discrimination, social behavior, unconditioned behaviors, cognition, PET imaging and pharmacological challenges in nonhuman primate models (rhesus and cynomolgus monkeys). We are also interested in neurochemical, physiological and hormonal changes due to cocaine exposure and we systematically study sex differences in our experimental results. In addition, my research program is the only one of its kind in the world funded to study socially housed monkeys (males and females) in intravenous drug self-administration studies.

 

Czoty PW, Gould RW, Martelle JL, Nader MA. Prolonged attenuation of the reinforcing strength of cocaine by chronic d-amphetamine in rhesus monkeys. Neuropsychopharmacology. 2011; 36(2):539-547. Czoty PW, Gage HD, Nader MA. Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine. Psychopharmacology (Berl). 2010; 208(4):585-592. Czoty PW, Martelle JL, Nader MA. Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys. Psychopharmacology (Berl). 2010; 209(4):375-382. Czoty PW, Coller M, Icenhower M, Nader MA. Effects of chronic administration of dopamine D2-like receptor agonists aripiprazole and (-)-N-propyl-norapomorphine on food/cocaine choice in socially housed monkeys [abstract]. FASEB J. 2010; 24(1 Meeting Abstracts):765.3. Hamilton LR, Wilson WD, Nader MA. Impulsivity and vulnerability to cocaine self-administration in adult rhesus monkeys exposed to cocaine in utero [abstract]. FASEB J. 2010; 24(1 Meeting Abstracts):765.5. Blaylock BL, Nader SH, Nader MA. Effects of varenicline on the discriminative stimulus effects of nicotine in female cynomolgus monkeys [abstract]. FASEB J. 2010; 24(1 Meeting Abstracts):580.3. Nader MA, Czoty PW, Nader SH. The effects of social hierarchy on cocaine reinforcement and brain interactions in male and female monkeys [abstract]. FASEB J. 2010; 24(1 Meeting Abstracts):765.4. Nader MA, Czoty PW, Gould RW, Riddick NV. Characterizing organism x environment interactions in non-human primate models of addiction: PET imaging studies of dopamine D2 receptors. In: Robbins TW, Everitt BJ, Nutt DJ, eds. The neurobiology of addiction: new vistas. New York: Oxford University Press; 2010: 187-202. Czoty PW, Martelle JL, Carroll FI, Nader MA. Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates. Pharmacol Biochem Behav. 2010; 96(3):274-278. Hamilton LR, Czoty PW, Gage HD, Nader MA. Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation. Psychopharmacology (Berl). 2010; 210(4):481-488. Martelle JL, Nader MA. A within-subject assessment of the discriminative stimulus and reinforcing effects of self-administered cocaine in rhesus monkeys. Psychopharmacology (Berl). 2009; 203(2):343-353. Riddick NV, Czoty PW, Gage HD, Kaplan JR, Nader SH, Icenhower M, Pierre PJ, Bennett A, Garg PK, Garg S, Nader MA. Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys. Neuroscience. 2009; 158(4):1257-1265. Czoty PW, Coller M, Icenhower M, Nader MA. Effects of aripiprazole and (-)NPA, dopamine D2-like receptor agonists of varying intrinsic efficacy, on cocaine vs. food choice in monkeys [abstract]. FASEB J. 2009; 23(Meeting Abstracts):588.3. Czoty PW, Gould RW, Nader MA. Relationship between social rank and cortisol and testosterone concentrations in male cynomolgus monkeys (Macaca fascicularis). J Neuroendocrinol. 2009; 21(1):68-76. Wilson TW, Godwin DW, Czoty PW, Nader MA, Kraft RA, Buchheimer NC, Daunais JB. A MEG investigation of somatosensory processing in the rhesus monkey. Neuroimage. 2009; 46(4):998-1003. Gould RW, Czoty PW, Nader SH, Nader MA. Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys [abstract]. FASEB J. 2009; 23(Meeting Abstracts):588.6. Nader MA, Czoty PW, Riddick NV, Gould RW, Gage HD. Social stress and vulnerability to cocaine abuse in nonhuman primate models [abstract]. Biol Psychiatry. 2009; 65(8 Suppl):176S. Nader MA, Riddick NV, Czoty PW, Icenhower M, Gage HD. Vulnerability to cocaine abuse in socially housed female monkeys: evidence for sex differences [abstract]. FASEB J. 2009; 23(Meeting Abstracts):588.8. Czoty PW, Riddick NV, Gage HD, Sandridge M, Nader SH, Garg S, Bounds M, Garg PK, Nader MA. Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeys. Neuropsychopharmacology. 2009; 34(3):548-554. Beveridge TJR, Smith HR, Nader MA, Porrino LJ. Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys. Neuropsychopharmacology. 2009; 34(5):1162-1171. Blaylock BL, Gould RW, Newman AH, Nader MA. Characterization of PG-619, a dopamine D3 receptor partial agonist, on cocaine self-administration and drug-elicited yawning in rhesus monkeys [abstract]. FASEB J. 2009; 23(Meeting Abstracts):588.4. Czoty PW, Nader MA. Effects of combined pharmacological and environmental manipulations on cocaine choice in monkeys [abstract]. Behav Pharmacol. 2009; 20(Special Issue 1):S75. Nader MA, Czoty PW, Hamilton LR, Riddick NV, Gould RW. Imaging of social stress, behavioral phenotype and cocaine reinforcement in monkey models [abstract]. Behav Pharmacol. 2009; 20(Special Issue 1):S12. Hamilton LR, Czoty PW, Calhoun TL, Nader MA. Impulsivity and vulnerability to cocaine self-administration in adult rhesus monkeys exposed to cocaine in utero [abstract]. FASEB J. 2009; 23(Meeting Abstracts):588.9. Banks ML, Czoty PW, Gage HD, Bounds MC, Garg PK, Garg S, Nader MA. Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys. Neuropsychopharmacology. 2008; 33(2):219-225. Banks ML, Czoty PW, Sprague JE, Nader MA. Influence of thyroid hormones on 3,4-methylenedioxymethamphetamine-induced thermogenesis and reinforcing strength in monkeys. Behav Pharmacol. 2008; 19(2):167-170. Nader MA, Czoty PW. Brain imaging in nonhuman primates: insights into drug addiction. ILAR J. 2008; 49(1):89-102. Banks ML, Gould RW, Czoty PW, Nader MA. Relationship between response rates and measures of reinforcing strength using a choice procedure in monkeys. Behav Pharmacol. 2008; 19(4):365-369. Nader MA, Czoty PW, Gould RW, Riddick NV. Positron emission tomography imaging studies of dopamine receptors in primate models of addiction. Philos Trans R Soc Lond B Biol Sci. 2008; 363(1507):3223-3232. Martelle JL, Czoty PW, Nader MA. Effect of time-out duration on the reinforcing strength of cocaine assessed under a progressive-ratio schedule in rhesus monkeys. Behav Pharmacol. 2008; 19(7):743-746. Banks ML, Sprague JE, Czoty PW, Nader MA. Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys. Psychopharmacology (Berl). 2008; 196(1):63-70. Martelle JL, Nader MA. A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride. CNS Neurosci Ther. 2008; 14(3):248-262. Sikoski P, Banks ML, Gould R, Young RW, Wallace JM, Nader MA. Comparison of rectal and infrared thermometry for obtaining body temperature in cynomolgus macaques (Macaca fascicularis). J Med Primatol. 2007; 36(6):381-384. Riddick NV, Czoty PW, Kaplan JR, Pierre P, Bennett A, Gage HD, Nader MA. Behavioral and neurochemical measures as predictors of social rank in female monkeys [abstract]. FASEB J. 2007; 21(6):A1179. Czoty PW, Gould RW, Nader SH, Nader MA. Lasting influence of social hierarchy on impulsivity and cocaine choice in cynomolgus [abstract]. FASEB J. 2007; 21(6):A781-A782. Czoty PW, Gage HD, Nader SH, Reboussin BA, Bounds M, Nader MA. PET imaging of dopamine D2 receptor and transporter availability during acquisition of cocaine self-administration in rhesus monkeys. J Addict Med. 2007; 1(1):33-39. Hamilton LR, Gage HD, Nader MA. Altered D2 receptor availability in adult rhesus monkeys exposed to cocaine in utero [abstract]. FASEB J. 2007; 21(6):A1179. Porrino LJ, Smith HR, Nader MA, Beveridge TJR. The effects of cocaine: a shifting target over the course of addiction. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(8):1593-1600. Martelle JL, Czoty PW, Nader MA. Chronic d-amphetamine treatment attenuates the reinforcing strength of cocaine in rhesus monkeys [abstract]. FASEB J. 2007; 21(6):A778. Martelle JL, Claytor R, Ross JT, Reboussin BA, Newman AH, Nader MA. Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzami e],. J Pharmacol Exp Ther. 2007; 321(2):573-582. Banks ML, Sprague JE, Kisor DF, Czoty PW, Nichols DE, Nader MA. Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys. Drug Metab Dispos. 2007; 35(10):1840-1845. Czoty PW, Reboussin BA, Calhoun TL, Nader SH, Nader MA. Long-term cocaine self-administration under fixed-ratio and second-order schedules in monkeys. Psychopharmacology (Berl). 2007; 191(2):287-295. Banks ML, Czoty PW, Nader MA. The influence of reinforcing effects of cocaine on cocaine-induced increases in extinguished responding in cynomolgus monkeys. Psychopharmacology (Berl). 2007; 192(4):449-456. Nader MA, Morgan D, Gage HD, Nader SH, Calhoun TL, Buchheimer N, Ehrenkaufer R, Mach RH. PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nat Neurosci. 2006; 9(8):1050-1056. Czoty PW, Martelle JL, Nader MA. Influence of abstinence and conditions of cocaine access on the reinforcing strength of cocaine in nonhuman primates. Drug Alcohol Depend. 2006; 85(3):213-220.