John McHaffie

Neuroscience PhD at Wake Forest University at Wake Forest University

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John McHaffie

  • E-mail:
  • Department: Neurobiology/Anatomy
  • Phone Number: (336) 716-9078
  • Research Interests: Physiological Relationships between Cortical and Subcortical Structures

McHaffie JG, Stein BE, Jiang H. Cross-modal rehabilitative training with auditory-visual cues ameliorates visual hemineglect in visual cortex lesioned cats [abstract]. Soc Neurosci Abstr. 2009; 2009(Neuroscience Meeting Planner):.

May PJ, McHaffie JG, Stanford TR, Jiang H, Costello MG, Coizet V, Hayes LM, Haber SN, Redgrave P. Tectonigral projections in the primate: a pathway for pre-attentive sensory input to midbrain dopaminergic neurons. Eur J Neurosci. 2009; 29(3):575-587.

Hudgins ED, McHaffie JG, Redgrave P, Salinas E, Stanford TR. Putative midbrain dopamine neurons encode sensory salience and reward prediction at different latencies [abstract]. Soc Neurosci Abstr. 2009; 2009(Neuroscience Meeting Planner):.

Coizet V, Graham JH, Moss J, Bolam JP, Savasta M, McHaffie JG, Redgrave P, Overton PG. Short-latency visual input to the subthalamic nucleus is provided by the midbrain superior colliculus. J Neurosci. 2009; 29(17):5701-5709.

Fuentes-Santamaria V, Alvarado JC, McHaffie JG, Stein BE. Axon morphologies and convergence patterns of projections from different sensory-specific cortices of the anterior ectosylvian sulcus onto multisensory neurons in the cat superior colliculus. Cereb Cortex. 2009; 19(12):2902-2915.

McHaffie JG. Cross-modal rehabilitative training ameliorates visuomotor deficits produced by visual cortex lesions [abstract]. In: Abstracts of the 10th International Multisensory Research Forum; 2009 June 29 – July 2; New York (NY). 2009; ():.

Jiang H, Stein BE, McHaffie JG. Neural correlates of cross-modal rehabilitative training in the deep superior colliculus of visual cortex lesioned cats [abstract]. Soc Neurosci Abstr. 2009; 2009(Neuroscience Meeting Planner):.

Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting discrimination of sensory features of pain: a new model. J Neurosci. 2009; 29(47):14924-1431.

Fuentes-Santamaria V, Alvarado Romero JC, McHaffie JG, Stein BE. Anatomical and physiological evidence for driver and modulator inputs in the anterior ectosylvian sulcus-superior colliculus pathway [abstract]. Histol Histopathol. 2009; 24(Suppl 1 Pt 59):S31.

Jiang H, Stein BE, McHaffie JG. Cortical lesion-induced visual hemineglect is prevented by NMDA antagonist pretreatment. J Neurosci. 2009; 29(21):6917-6925.

Hadsel MS, Quevedo A, Oshiro Y, Houle TT, McHaffie JG, Kraft RA, Coghill RC. Precuneus/posterior cingulate cortex activity in experimental pain–a functional magnetic resonance imaging (FMRI) study [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008; ():PF 139.

Fuentes-Santamaria V, McHaffie JG, Stein BE. Anterior ectosylvian subregions send converging inputs with multiple morphologies to multisensory superior colliculus neurons [abstract]. Soc Neurosci Abstr. 2008; 2008(Neuroscience Meeting Planner):.

Jiang H, Stein BE, McHaffie JG. Cross-modal rehabiliative training reinstates lost visual responsiveness to deep superior colliculus (SC) neurons [abstract]. Soc Neurosci Abstr. 2008; 2008(Neuroscience Meeting Planner):.

Fuentes-Santamaria V, Alvarado JC, Stein BE, McHaffie JG. Cortex contacts both output neurons and nitrergic interneurons in the superior colliculus: direct and indirect routes for multisensory integration. Cereb Cortex. 2008; 18(7):1640-1652.

Fuentes-Santamaria V, McHaffie JG, Stein BE. Maturation of multisensory integration in the superior colliculus: expression of nitric oxide synthase and neurofilament SMI-32. Brain Res. 2008; 1242():45-53.

McHaffie JG, Stein BE, Jiang H. Cross-modal rehabiliative training ameliorates visumotor deficits in visual cortex lesioned cats [abstract]. Soc Neurosci Abstr. 2008; 2008(Neuroscience Meeting Planner):.

Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting spatial discrimination of pain. J Neurosci. 2007; 27(13):3388-3394.

Fathke R Jr, McHaffie J, Henkel C, Gabriele M. Patterns of convergence for multiple afferent projections to the central nucleus of the inferior colliculus prior to the onset of hearing [abstract]. Assoc Res Otolaryngol Abstr. 2007; 30():285.

Gabriele ML, Shahmoradian SH, French CC, Henkel CK, McHaffie JG. Early segregation of layered projections from the lateral superior olivary nucleus to the central nucleus of the inferior colliculus in the neonatal cat. Brain Res. 2007; 1173():66-77.

Fuentes-Santamaria V, McHaffie JG, Stein BE. Development of the cortico-collicular circuitry underlying multisensory integration involves nitric oxide containing interneurons [abstract]. Soc Neurosci Abstr. 2007; 2007(Abstr Viewer):.

Coizet V, McHaffie J, May P, Stanford T, Jiang H, Costello Grinberg M, Graham J, Overton P, Redgrave P. The tecto-subthalamic projection: a source of short-latency visual input to the subthalamic nucleus [abstract]. Parkinsonism Relat Disord. 2007; 13(Suppl 2):S41.

Jiang H, Stein BE, McHaffie JG. Deactivation of crossed nigrotectal neurons reinstates visual responsiveness in deep laminae superior colliculus (SC) neurons following large visual cortex lesions [abstract]. Soc Neurosci Abstr. 2007; 2007(Abstr Viewer):.

Gabriele ML, Fathke RL, Shahmoradian SH, French CC, Henkel CK, McHaffie JG. Segregation of multiple layered projections to the central nucleus of the inferior colliculus in the neonatal cat [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer):.

May PJ, McHaffie JG, Jiang H, Stanford TR, Costello MG, Haber SN, Coizet V, Redgrave P. Projections from the superior colliculus to substantai nigra pars compacta in a primate [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer):.

Jiang H, Stein BE, McHaffie JG. NMDA antagonist pretreatment prevents visual orientation deficits induced by visual cortex lesions and facilitates postlesion acquisition of pattern discrimination [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer):.

Fuentes-Santamaria V, McHaffie JG, Stein BE. Postnatal maturation of converging visual and auditory cortico-collicular inputs onto multisensory superior colliculus neurons [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer):.

McHaffie JG, Jiang H, Stanford TR, Costello MG, Redgrave P, Coizet V, May PJ. The subthalamic nucleus receives afferents from the superior colliculus in cats and macaque monkeys [abstract]. Soc Neurosci Abstr. 2006; 2006(Abstr Viewer):.

McHaffie JG, Jiang H, Stein BE. Superior colliculus mediated visuomotor function depends on coupling global inhibition and focal disinhibition. In: Bezard E, ed. Recent breakthroughs in basal ganglia research. New York: Nova Science Publishers; 2006: 173-184.

 

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The brain is composed of a host of different regions, each seemingly devoted to specific functions. Yet, in order to produce even relatively ‘simple’ behaviors, like noticing a bird flying across the evening sky, requires the coordinated activity of many structures through complex neural networks. In an effort to determine how the interplay of multiple brain regions leads to adaptive behaviors, our laboratory is currently focused on understanding the neuroanatomical and physiological relationships among the cortex, midbrain superior colliculus, and the basal ganglia. Our long term goal is to facilitate the development of therapies for ameliorating sensory neglect in patients, much like manipulations of the basal ganglia are currently being used to treat motor dysfunctions associated with Parkinson’s Disease.