Jay Kaplan, Ph.D.
Dr. Kaplan has primary appointments as Professor of Pathology (Comparative Medicine) and Translational Medicine. He also serves as Director of the Wake Forest University Primate Center and the Head of the Section on Comparative Medicine. He received his BA from Swarthmore College and then earned an MA and PhD in Biological Anthropology from Northwestern University. Dr. Kaplan’s career long research interest has been in evaluating behavioral and hormonal effects on disease vulnerability, particularly in relation to cardiovascular disease. He began his studies with male monkeys, demonstrating that behaviorally-induced arousal of the sympathetic nervous system could exacerbate atherosclerosis; he evaluated the underlying mechanisms with several studies involving beta-adrenergic blocking agents. He also has maintained a career-long interest in women’s health, especially as influenced by psychosocial factors. At present he explores the relationship between behaviorally-induced impaired premenopausal ovarian function and the increased trajectory of risk for the chronic and degenerative diseases that comprise the majority of the postmenopausal health burden.
Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB. Genetics and development of obesity in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Phys Anthropol. 2013;150(Suppl 56):243.
Ethun KF, Wood CE, Parker CR, Kaplan JR, Chen H, Appt SE. Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque model. Climacteric. 2012;15(1):82-92.
Shelton KA, Clarkson TB, Kaplan JR.Nonhuman primate models of atherosclerosis
O'Grady SP, Valenzuela LO, Remien CH, Enright LE, Jorgensen MJ, Kaplan JR, Wagner JD, Cerling TE, Ehleringer JR. Hydrogen and oxygen isotope ratios in body water and hair: modeling isotope dynamics in nonhuman primates. Am J Primatol. 2012;74(7):651-660.
Wood CE, Stavisky RC, Nowak J, Kaplan JR. Stimulatory adrenocortical effects of a selective estrogen receptor modulator in ovariectomized female macaques. Toxicol Pathol. 2012;40(1):55-61.
Nader MA, Nader SH, Czoty PW, Riddick NV, Gage HD, Gould RW, Blaylock BL, Kaplan JR, Garg PK, Davies HML, Morton D, Garg S, Reboussin BA. Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement. Biol Psychiatry. 2012;72(5):414-421.
Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012;19(9):967-973.
Jorgensen MJ, Rudel LL, Kavanagh K, Jasinska AJ, Freimer NB, Jentsch JD, Fairbanks LA, Fallon MT, Kaplan JR. The vervet research colony as a biomedical resource [abstract]. Am J Primatol. 2012;74(Suppl 1):68.
Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.
Jorgensen MJ, Rudel LL, Nudy M, Kaplan JR, Clarkson TB, Pajewski NM, Schnatz PF. 25(OH)D3 and cardiovascular risk factors in female nonhuman primates. J Womens Health. 2012;21(9):959-965.
Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE.The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Menopause. 2012;19(10):1074-1080.
Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas. 2012;73(2):143-147.
Appt SE, Chen H, Clarkson TB, Kaplan JR. Premenopausal antimullerian hormone concentration is associated with subsequent atherosclerosis. Menopause. 2012;19(12):1353-1359.
Kavanagh K, Dozier BL, Chavanne TJ, Fairbanks LA, Jorgensen MJ, Kaplan JR.Fetal and maternal factors associated with infant mortality in vervet monkeys. J Med Primatol. 2011;40(1):27-36.
Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17 beta-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Res. 2011;1379():11-22.
Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Res. 2011;1379():23-33.
Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ. Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. Genes Brain Behav. 2011;10(6):683-688.
Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ. Environmental stress alters genetic regulation of novelty seeking in vervets [abstract]. Am J Primatol. 2011;73(Suppl 1):84.
Kuhrt D, Nusbaum R, Garlena R, Nguyen T, Jorgensen MJ, Silvestri G, Kaplan J, Apetrei C, Pandrea I. CCR5 expression on CD4+T cells and not CD4 downregulation impacts the efficacy of SIVagm mucosal transmission in African green monkeys (AGMS) [abstract]. J Med Primatol. 2011;40(4):256.
Voruganti V, Jorgensen MJ, Kaplan JR, Kauanagh K [sic] [Kavanagh K], Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (GXD) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in Vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Primatol. 2011;73(Suppl 1):84.
Appt SE, Kavanagh K, Chen H, Kaplan JR, Lazar J, Clarkson TB. Pulse wave velocity is positively correlated with atherosclerosis extent in midlife female nonhuman primates [abstract]. Menopause. 2011;18(12):1348.
Jorgensen MJ, Schnatz PF, Rudel LL, Nudy M, Kaplan JR, Clarkson TB. Low plasma concentrations of vitamin D3 are associated with increased cardiovascular risk factors in a female nonhuman primate model [abstract]. Menopause. 2011;18(12):1345.
Schnatz PF, Vila-Wright S, Jiang X, Register TC, Appt SE, Kaplan JR, Clarkson TB.An inverse relationship between plasma vitamin D concentrations and C-reactive protein provides a potential mechanism for cardioprotection [abstract]. Menopause. 2011;18(12):1352.
Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res. 2010;16(3):946-956.
Jones JC, Appt SE, Werre SR, Tan JC, Kaplan JR. Validation of multi-detector computed tomography as a non-invasive method for measuring ovarian volume in macaques (Macaca fascicularis). Am J Primatol. 2010;72(6):530-538.
Christ GJ, Melman A, Williams K, Aboushwareb T, Zhao WX, Kaplan J, Anderson K-E [sic] [Andersson K-E]. Nonhuman primates as a model for translational research on atherosclerosis-related vascular disease and erectile dysfunction [abstract]. J Sex Med. 2010;7(Suppl 1):46.
Appt SE, Chen H, Goode AK, Hoyer PB, Clarkson TB, Adams MR, Wilson ME, Franke AA, Kaplan JR. The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis). Menopause. 2010;17(4):741-748.
Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC, Persyn JT, Ethun KF, Chen H, Kaplan JR, et al. Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Comp Med. 2010;60(5):380-388.
Kaplan JR, Chen H, Appt SE, Lees CJ, Franke AA, Berga SL, Wilson ME, Manuck SB, Clarkson TB. Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet. Hum Reprod. 2010;25(12):3083-3094.
Jolly CJ, Phillips-Conroy JE, Kaplan J, Bergman T, Mann JJ. Monoamine metabolites in the CSF of male anubis (Papio anubis) and hamadryas (P. hamadryas) baboons parallel their species-specific behavioral ontogeny [abstract]. Am J Phys Anthropol. 2009;138(Suppl 48):160-161.
Muhammad FS, Goode AK, Kock ND, Arifin EA, Cline JM, Adams MR, Hoyer PB, Christian PJ, Isom S, Kaplan JR, Appt SE. Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. Comp Med. 2009;59(1):46-59.
Riddick NV, Czoty PW, Gage HD, Kaplan JR, Nader SH, Icenhower M, Pierre PJ, Bennett A, Garg PK, Garg S, Nader MA. Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys. Neuroscience. 2009;158(4):1257-1265.
Appt SE, Clarkson TB, Chen H, Adams MR, Christian PJ, Hoyer PB, Wilson ME, Kaplan JR. Serum antimullerian hormone predicts ovarian reserve in a monkey model. Menopause. 2009;16(3):597-601.
Appt SE, Clarkson TB, Chen H, Adams MR, Christian PJ, Hoyer PB, Wilson ME, Kaplan JR. Serum antimullerian hormone predicts ovarian reserve in a monkey model [abstract]. J Womens Health. 2009;18(5):744.
Wagner JD, Jorgensen MJ, Cline JM, Lees CJ, Franke AA, Zhang L, Ayers MR, Schultz C, Kaplan JR. Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring. Am J Primatol. 2009;71(9):802-811.
Jolly CJ, Phillips-Conroy J, Kaplan J, Mann JJ. Monoamine metabolites in the CSF of male anubis (Papio anubis) and hamadryas (P. hamadryas) baboons parallel their species-specific behavioral ontogeny [abstract]. Am J Primatol. 2009;71(Suppl 1):64.
Kaplan JR, Chen H, Manuck SB. The relationship between social status and atherosclerosis in male and female monkeys as revealed by meta-analysis. Am J Primatol. 2009;71(9):732-741.
Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R Jr, Kaplan J, Aboushwareb T, Yoo J, Calenda G, Davies KP, et al. Smooth-muscle-specific gene transfer with the human Maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys. Eur Urol. 2009;56(6):1055-1066.
Chen Z, van Doorslaer K, DeSalle R, Wood CE, Kaplan JR, Wagner JD, Burk RD.Genomic diversity and interspecies host infection of alpha 12 Macaca fascicularis papillomaviruses (MfPVs). Virology. 2009;393(2):304-310.
Michopoulos V, Berga SL, Kaplan JR, Wilson ME. Social subordination and polymorphisms in the gene encoding the serotonin transporter enhance estradiol inhibition of luteinizing hormone secretion in female rhesus monkeys. Biol Reprod. 2009;81(6):1154-1163.
Shively CA, Register TC, Kritchevsky S, Carr JJ, Kaplan JR, Jorgensen MJ, Bennett AJ. A primate model of physical function [abstract]. Gerontologist. 2009;49(Suppl 2):65-66.
Jarrell H, Hoffman JB, Kaplan JR, Berga S, Kinkead B, Wilson ME.Polymorphisms in the serotonin reuptake transporter gene modify the consequences of social status on metabolic health in female rhesus monkeys. Physiol Behav. 2008;93(4-5):807-819.
Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R, Kaplan J, Aboushwareb T, Yoo J, Davies K, Melman A. MAXI-K gene transfer with a smooth muscle specific promoter enhances erectile function and sexual behaviour in atherosclerotic cynomolgous monkeys [abstract]. Eur Urol. 2008;7(3 Suppl):143.
Gratzke C, Christ GJ, Kaplan JR, Stief CG, Andersson KE, Badlani G. Chronic soy and phytoestrogen treatment leads to significant functional and morphological changes in the urethra of oophorectomized female non-human primates [abstract]. Eur Urol. 2008;7(3 Suppl):315.
Gratzke C, Christ GJ, Kaplan JR, Andersson K-E, Badlani G. Chronic soy and phytoestrogen treatment leads to significant functional and morphological changes in the urethra of female non-human primates [abstract]. Neurourol Urodyn. 2008;27(2):106.
Miller-Butterworth CM, Kaplan JR, Shaffer J, Devlin B, Manuck SB, Ferrell RE.Sequence variation in the primate dopamine transporter gene and its relationship to social dominance. Mol Biol Evol. 2008;25(1):18-28.
Wagner JD, Zhang L, Shadoan MK, Kavanagh K, Chen H, Tresnasari K, Kaplan JR, Adams MR. Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys. Metabolism. 2008;57(Suppl 1):S24-S31.
Kaplan JR. Origins and health consequences of stress-induced ovarian dysfunction. Interdiscip Top Gerontol. 2008;36():162-185.
Kaplan JR, Manuck SB. Ovarian dysfunction and the premenopausal origins of coronary heart disease. Menopause. 2008;15(4 Pt 1):768-776.
Gratzke C, Jarajapu YPR, Christ GJ, Kaplan JR, Williams JK, Andersson K-E, Badlani G. Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates. J Urol. 2008;180(5):2247-2253.
Walker SE, Register TC, Appt SE, Adams MR, Clarkson TB, Chen H, Isom S, Franke AA, Kaplan JR. Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden. Menopause. 2008;15(5):950-957.
Appt SE, Clarkson TB, Adams MR, Hoyer PB, Christian PJ, Kaplan JR. Dietary soy with isoflavones retards ovarian aging [abstract]. Menopause. 2008;15(6):1210.
Jolly CJ, Phillips-Conroy JE, Kaplan JR, Mann JJ. Cerebrospinal fluid monoaminergic metabolites in wild Papio anubis and P.hamadryas are concordant with taxon-specific behavioral ontogeny. Int J Primatol. 2008;29(6):1549-1566.
Ethun K, Kavanagh K, Kaplan JR. Chronic experimental high-fat diet exposure leads to coagulopathy in African green monkeys (Chlorocebus aethiops saebeus) [abstract]. J Am Assoc Lab Anim Sci. 2008;47(5):108.