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Neuroscience PhD at Wake Forest University at Wake Forest University


Wake Forest University Graduate School » Neuroscience PhD at Wake Forest University

Hariom Yadav, PhD

Hariom Yadav, PhD
We are specifically investing: 1) how gut microbiome interacts with enteroendocrine and enteric nervous cells to manipulate gut motility and food intake 2) what is the role of gut virome in obesity and diabetes 3) how gut microbiome can contribute in drug responsiveness. Our ultimate goal is to develop gut microbiome modulators to curve obesity and diabetes, as well as develop gut microbiome based biomarkers to predict drug efficacy and disease prevalence.

 

  1. Yadav H, Devalaraja S, Chung S, Rane SG. 2017. TGF-β1/Smad3 pathway targets PP2A-AMPK-FoxO1 to regulate hepatic gluconeogenesis. Journal of Biological Chemistry, jbc. M116. 764910.
  2. Angmo A, Tripathi N, Abbat S, Sharma S, Singh SS, Halder A, Yadav K, Shukla G, Sandhir R, Rishi V, Bharatam PV, Yadav H*, Singhal NK*. 2017. Guanosine 5ʹ-diphosphate increases iron absorption in mice by inhibiting hepcidin-ferroportin interaction. Scientific Reports 7:40097. doi:10.1038/srep40097.
  3. Kelley EE, de Andrade Paes AM, Yadav H, Quijano C, Cassina A, Trostchansky A. 2017. Interplay between Oxidative Stress and Metabolism in Signalling and Disease. Oxidative Medicine and Cellular Longevity doi:10.1155/2017/7013972
  4. Wankhade UD, Shenc M, Yadav H, Thakali KM. 2016. Beige adipose tissue - novel beiging agents, mechanism(s) and therapeutic potential. BioMed Research International; ID 2365609, 15 pages, doi:10.1155/2016/2365609
  5. Develaraja S, Reddy A, Yadav M, Jain S, Yadav H*. 2016. Whole grains in amelioration of metabolic derangements. J Nutritional Health and Food Science 4(4): 1-11.DOI: http://dx.doi.org/10.15226/jnhfs.2016.00173
  1. Yadav H*, Jain S. 2016. Possible mystery behind higher susceptibility of type 2 diabetes in Asian Indians: is it diet, genetics or something else. J Nutr Health Food Eng 5(1): 00159.
  2. Yadav H*, Jain S, Nagpal R, Marotta F. 2016. Increased fecal viral content associated with obesity in mice. World J Diabetes 7(15): 316-320.
  3. Yadav H*, Jain S, Bissi L, Marotta F. 2016. Gut microbiome derived metabolites to regulate energy homeostasis: how microbiome talks to host. Metabolomics 6: e150.
  4. Mukhija K, Singhal K, Angmo S, Yadav K, Yadav H, Sandhir R, Singhal NK*. 2016. Potential of alginate encapsulated ferric saccharate microemulsions to ameliorate iron deficiency in mice. Biol Trace Elem Res, 172: 179-192.
  5. Nagpal R, Kumar M, Yadav AK, Hemalatha R, Yadav H, Marotta F, Yamashiro Y. 2016. Gut microbiota in health and disease: an overview focused on metabolic inflammation. Beneficial Microbes, 1-14.
  6. Yadav H, Rane S*. 2015. Dietary Fatty Acids: Friends or Foe? Obesity 23 (7), 1329-1329.
  7. Nagpal R, Yadav H, Marotta F*. 2014. Gut microbiota: the next-gen frontier in preventive and therapeutic medicine? Frontiers in Medicine 1: 15.
  8. Yadav H, Lee JH, Lylod J, Walter P, Rane SG*. 2013. Beneficial metabolic effects of a probiotic via butyrate induced GLP-1 secretion. Journal of Biological Chemistry 288: 25088-97.
  9. Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright E, Lonning S, Krause M, Skarulis M, Sumner A, Finkle T, and Rane SG*. 2011. Protection from obesity and diabetes by blockade of TGF-b/Smad3 signaling. Cell Metabolism14:67-79.
        Also highlighted in: a).  Nature Drug Discovery Highlights. 2011. Turning “bad” fat into “good”. Nature                      Drug            Discovery 10, 659. b).  Nature Highlights. 2011. Bad fat makes good. Nature, 475: 143.
  1. Kim YC, Kim SY, Mellado-Gil JM, Yadav H, Neidermyer W, Kamaraju AK, Rane SG*. 2011. RB regulates pancreas development by stabilizing Pdx1. EMBO Journal30:1563-76.
  2. Yadav M, Lavania A, Tomar R, Prasad GBKS, Jain S and Yadav H*. 2009. Complementary and Comparative Study on Hypoglycemic and Antihyperglycemic Activity of Various Extracts of Eugenia jambolana Seed, Momordica charantiaFruits, Gymnema sylvestre, and Trigonella foenum graecum Seeds in Rats. Applied Biochemistry and Biotechnology. 160:2388-400.
  3. Pachauri A1Yadav H1*, Jain S, Bisen PS, Chapperwal A, Marotta F, Minelli E and Prasad GBKS. 2009. Hypoglycemic effect of Diabegon; a polyherbal preparation in normal and type 2 diabetic rats and human subjects. The International Medical Journal16: 117-124. (1Contributed equally)
  4. Lin HM, Lee JH, Yadav H, Kamaraju AK, Gavrilova O, Liu E, Vieira A, Kim SJ, Collins H, Matschinsky H, Harlan DM, Roberts AB and Rane SG*. 2009. TGF-β/Smad3 signaling regulates insulin gene transcription, pancreatic islet β-cell function and insulin action.Journal of Biological Chemistry284:12246-57.
  5. Jain S1Yadav H1*and Sinha PR. 2009. Antioxidant, cholesterol assimilation and angiotensin converting enzyme inhibiting activities of selected lactobacilli and lactococci cultures. Journal of Dairy Research 76: 385-391. (1Contributed equally)
  6. Jain S*, Yadav Hand Sinha PR. 2009. Probiotic dahi containing Lactobacillus casei protects against Salmonella enteritidis infection and modulates immune response in mice. Journal of Medicinal Food 12: 576-583.
  7. Jain S*, Yadav H,Sinha PR and Marotta F. 2009. Modulation of cytokine gene expression in spleen and peyer’s patches by feeding of dahi containing probiotic Lactobacillus casei in mice. Journal of Digestive Diseases, 10: 49–54.
  8. Yadav H*,Jain S, Sinha PR and Marotta F. 2009. Epigenomic derangement of hepatic glucose metabolism by feeding of high fructose diet and its prevention by Rosiglitazone in rats. Digestive and Liver Diseases 41:500-508.
  9. Yadav H*, Yadav M, Jain S, Bhardwaj A, Singh V, Parkash O and Marotta F. 2008. Antimicrobial property of a herbal preparation containing Dalbergia sissoo and Datura stramoniumwith cow-urine against pathogenic bacteria. International Journal of Immunopathology and Pharmacology 21:1013-20.
  10. Jain S1Yadav H1*, Sinha PR, Naito Y and Marotta F. 2008. Dahi containing probiotic Lactobacillus acidophilusand Lactobacillus casei has protective effect against Salmonella enteritidis infection in mice. International Journal of Immunopathology and Pharmacology 21:1021-9. (1Contributed equally)
  11. Jain S, Yadav H*and Sinha PR. 2008. Stimulation of innate immunity by oral administration of probiotic dahi containing Lactobacillus casei in mice. Journal of Medicinal Food11:652-656.
  12. Yadav H*, Jain S and Sinha PR. 2008. Oral administration of dahi containing probioticLactobacillus acidophilusand Lactobacillus casei ameliorated the Streptozotocin-induced oxidative stress and dyslipidemia in rats. Journal of Dairy Research 75:189-195.
  13. Yadav H*, Jain S and Sinha PR. 2008. The effect of probiotic dahi containing Lactobacillus acidophilusand Lactobacillus casei on gastropathic consequences in diabetic rats. Journal of Medicinal Food 11: 62-68.
  14. Agrawal OP*, Pachauri A, Yadav H, Urmila J, Goswamy HM, Chapperwal A, Bisen PS, Prasad GB*. 2007. Subjects with impaired glucose tolerance exhibit a high degree of tolerance to honey. Journal of Medicinal Food10: 473-478.
  15. Yadav H*, Jain S, and Sinha PR. 2007. Evaluation of changes during storage of probiotic dahi at 70International Journal of Dairy Technology 46: 1-6.
  16. Yadav H*, Jain S and Sinha PR. 2007. Production of free fatty acids and conjugated linoleic acid in probiotic dahi containing Lactobacillus acidophilusand Lactobacillus casei during fermentation and storage. International Dairy Journal 60: 1006-1010.
  17. Yadav H*, Jain S and Sinha PR. 2007. Study of oligosaccharide formation during storage of skim milk fermented with Lactococci and Lactobacilli bacteria. Journal of Dairy Research 74: 154-159.
  18. Yadav H*, Jain S and Sinha PR. 2007. Anti-diabetic effect of probiotic dahi containingLactobacillus acidophilus, Lactobacillus casei and Lactococcus lactisbacteria in high fructose diet fed rats. Nutrition 72: 62-68.
  19. Yadav H*, Jain S, Prasad GBKS and Yadav M. 2007. Preventive effect of diabegon; a polyherbal preparation during progression of diabetes in high fructose fed rats. Journal of Pharmacological Sciences105: 12-21.
  20. Yadav H*,Jain S and Sinha PR. 2006. Effect of skim milk and dahi on blood glucose, insulin and lipid profile in high fructose diet fed rats. Journal of Medicinal Food 9(3): 328-335.
  21. Yadav H*,Jain S and Sinha PR. 2006. Effect of dahi containing Lactococcus lactis on progression of diabetes induced by high fructose diet in rats. Bioscience, Biotechnology and Biochemistry 70(5):1255-1258.
*Corresponding Author(s)