My research is focused on understanding the neurochemical mechanisms that support the reinforcing and motivating actions of abused drugs and lead to the development of addiction. My particular emphasis is how drugs of abuse induce changes in the delicate equilibrium between synaptic processes such as release, reuptake and synthesis of brain neurotransmitters in response to acute and repeated drug exposure. I am currently focused on the dysregulation of these neurochemical events in the mesolimbic and nigrostriatal dopamine systems during drug addiction. My primary objective is to combine cutting edge molecular and genetic techniques with sophisticated neurochemical approaches to understand how abused drugs dysregulate neurotransmission.
Evgeny Budygin, Ph.D.
Bass CE, Grinevich VP, Vance ZB, Sullivan RP, Bonin KD, Budygin EA. Optogenetic control of striatal dopamine release in rats. J Neurochem. 2010; 114(5):1344-1352.
Zimin IA, Abaimov DA, Budygin EA, Zolotarev IuA, Kovalev GI. [Role of the brain dopaminergic and serotoninergic systems in psychopharmacological effects of ladasten and sydnocarb] [Russian]. Eksp Klin Farmakol. 2010; 73(2):2-5.
Anstrom KK, Miczek KA, Budygin EA. Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats. Neuroscience. 2009; 161(1):3-12.
Mathews TA, Brookshire BR, Budygin EA, Hamre K, Goldowitz D, Jones SR. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol. 2009; 43(6):421-431.
Oleson EB, Salek J, Bonin KD, Jones SR, Budygin EA. Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice. Neurosci Lett. 2009; 467(2):144-146.
O’Connor JA, Budygin EA, Grinevich VP, Bencherif M. Effect of partial nicotinic agonists on real-time dopamine responses in rat nucleus accumbens: in vivo voltammetric study [abstract]. Biochem Pharmacol. 2009; 78(7):917.
Oleson EB, Talluri S, Childers SR, Smith JE, Roberts DCS, Bonin KD, Budygin EA. Dopamine uptake changes associated with cocaine self-administration. Neuropsychopharmacology. 2009; 34(5):1174-1184.
Grinevich VP, O’Connor JA, Bencherif M, Budygin EA. Effects of nicotine on real-time dopamine dynamics in rat nucleus accumbens: in vivo voltammetric study [abstract]. Biochem Pharmacol. 2009; 78(7 Special Issue):916.
Mathews TA, Brookshire BR, Budygin EA, Daunais JB, Friedman DP, Jones SR. A neurochemical comparison of striatal dopamine function in drinking monkeys [abstract]. Alcohol Clin Exp Res. 2008; 32(6 Suppl 1):35A.
Budygin EA. Dopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior. Neurosci Lett. 2007; 429(1):55-58.
Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz M, McCool BA, Jones SR. Terminal effects of chronic alcohol exposure on dopamine dynamics in rat striatum [abstract]. Alcohol Clin Exp Res. 2007; 31(6 Suppl):83A.
Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007; 193(4):495-501.
Chen KC, Budygin EA. Extracting the basal extracellular dopamine concentrations from the evoked responses: re-analysis of the dopamine kinetics. J Neurosci Methods. 2007; 164(1):27-42.
John CE, Budygin EA, Weiner JL, Jones SR. NMDA receptor deficient mice display altered synaptic function and reward related behaviors [abstract]. Neuropsychopharmacology. 2006; 31(Suppl):S76.
Budygin EA, Jones SR. Accumbal dopamine release, but not uptake or synthesis, is altered by low and moderate doses of acute ethanol [abstract]. Alcohol Clin Exp Res. 2006; 30(6 Suppl):182A.
Mathews TA, John CE, Lapa GB, Budygin EA, Jones SR. No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse. 2006; 60(4):288-294.
Coming soon . .