David Friedman, Ph.D.

Neuroscience PhD at Wake Forest University at Wake Forest University


Wake Forest University Graduate School » Neuroscience PhD at Wake Forest University » People » David Friedman, Ph.D.

David Friedman, Ph.D.

David Friedman, Ph.D.
  • E-mail:
  • Department: Physiology & Pharmacology
  • Phone Number: (336) 716-7186
  • Research Interests: Substance Abuse , Education Outreach , Neurosciences/Behavior
  • Faculty Page: http://profiles.tsi.wakehealth.edu/display/105811

The Friedman lab uses alcohol self-administration in non-human primates to study the effects of alcohol on the brain.  Brains are studied using both in vivo (PET, MRI) and in vitro (quantitative in vitro receptor autoradiogaphy, cell counting and volume analysis) approaches.

 

Friedman DP, Jones EG.  Focal projection of electrophysiologically defined groupings of thalamic cells in the monkey somatic sensory cortex.  Brain Res 1980; 191:249?252.

Friedman DP, Horvath FE.  Catecholaminergic involvement in phasic vs. tonic electrocortical arousal.  Brain Res 1980; 194:572?577.

Friedman DP, Jones EG, Burton HB.  Representation pattern in the second somatic sensory area of the monkey cerebral cortex.  J Comp Neurol 1980; 192:21?42.

Friedman DP, Jones EG.  Thalamic input to areas 3a and 2 in monkeys.  J Neurophysiol 1981; 45:59?85.

Jones EG, Friedman DP.  Projection pattern of functional components of thalamic ventrobasal complex upon monkey somatic sensory cortex.  J Neurophysiol 1982; 48:521?544

Jones EG, Friedman DP, Hendry SHC.  Thalamic basis of place? and modality-specific columns in monkey somatic sensory cortex:  A correlative anatomical and physiological study.  J Neurophysiol 1982; 48:545?568

Friedman DP.  Laminar patterns of termination of cortico?cortical afferents in the somatosensory system.  Brain Res 1983; 273:147?151

Bachevalier J, Ungerleider LG, O’Neill JB, Friedman DP.  Regional distribution of [3H] Naloxone binding in the brain of a newborn rhesus monkey.  Devel Brain Res 1986; 25:302?308.

Friedman DP, Murray EA, O’Neill JB, Mishkin M.  Cortical connections of the somatosensory fields of the lateral sulcus of macaques:  evidence for a corticolimbic pathway for touch.  J Comp Neurol 1986; 252:323?347

Friedman DP, Murray EA.  Thalamic connectivity of the second somatosensory area and the neighboring somatosensory fields of the lateral sulcus of the macaque.  J Comp Neurol 1986; 252:348?373.

Pons TP, Garraghty PE, Friedman DP, Mishkin M.  Physiological evidence for serial processing in somatosensory cortex.  Science 1987; 237:417?420.

Aggleton JP, Friedman DP, Mishkin M.  A comparison between the connections of the amygdaloid complex and the hippocampal formation with the basal forebrain in the macaque monkey.  Exp Brain Res 1987; 67:556?568.

Nelson RB, Friedman DP, O’Neill JB, Mishkin M, Routtenberg A.  Gradients of protein kinase C substrate phosphorylation in primate visual system peak in visual memory storage areas. Brain Res 1987; 416:387?392.

Huang FL, Yoshida, Y, Nakbayashi, H, Friedman, DP, Ungerleider, LG, Young WS, Huang, KP. Type I protein kinase C isozyme in the visual information-processing pathway of the monkey brain.  J Cell Biochem 1989: 39:401-410. 

Juliano SL, Friedman DP, Eslin DE.  Corticocortical connections predict patches of stimulus?evoked metabolic activity in monkey somatosensory cortex.  J Comp Neurol 1990; 298:23-39.

Schneider RJ, Friedman DP, Mishkin M. A modality-specific somatosensory area within the insula of the rhesus monkey.  Brain Res 1993; 621:116-120.

Lyons DL, Friedman DP, Nader MA, Porrino LJ. Cocaine alters cerebral metabolism within the ventral striatum and limbic cortex of monkeys. J Neurosci 1996;16:1230-1238,

Moore, RJ, Vinsant, SL, Nader MA, Porrino, LJ, Friedman, DP. The effect of cocaine self-administration on striatal D1 dopamine receptors in rhesus monkey.  Synapse 1998; 28:1-9.

Moore, RJ, Vinsant, SL, Nader MA, Porrino, LJ, Friedman, DP.  Cocaine self-administration decreases dopamine D2 receptors in the nigrostriatal pathway in rhesus monkeys Synapse 199830:88-96.

Krob HA, Vinsant SL, Averill DB, Ferrario CM, Friedman DP. Angiotensin- (1-7) Immunoreactivity in the hypothalamus of the (mRen-2d) 27 transgenic rat.  Brain Research 1998; 797:36-45.

Letchworth, SL, Nader, MA, Smith, HR, Friedman, DP, Porrino, LJ.  Progression of changes in dopamine transporter binding site density as a result of cocaine self?administration in rhesus monkeys. J Neurosci. 2001; 21,2799?807.

Freeman WM, Nader MA, Nader SH, Robertson DJ, Gioia L, Mitchell SM, Daunais JB,  Porrino LJ, Friedman DP, Vrana, KE. Chronic cocaine?mediated changes in non?human primate nucleus accumbens gene expression. J Neurochem  2001; 77:542?9.

Nader MA, Daunais, JB, Moore, T, Nader, SH, Moore RJ, Smith, HR, Friedman, DP, Porrino, LJ.  Effects of cocaine self-amdinistration on striatal dopamine systems in rhesus monkeys: intitial and chronic exposure.  Neuropsychopharmacology. 2002; 27: 35-46.

Porrino, LJ, Lyons, D, Miller MD, Smith HR, Friedman, DP, Daunais, JB, Nader MA.  Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primate.  J Neurosci. 2002 Sep 1;22(17):7687-94.

Friedman DP, Aggleton, JP, Saunders, RC.  Comparison of the hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: Combined anterograde and retrograde tracing study in the macaque brain. J. Comp Neurol. 2002; 450:345-365.

Budygin EA, John CE, Mateo Y, Daunais JB, Friedman DP, Grant KA, Jones SR. Chronic ethanol exposure alters presynaptic dopamine function in the striatum of monkeys: a preliminary study.  Synapse 2003; 50: 266-8.

Ariwodola OJ, Crowder TL, Grant KA, Daunais JB, Friedman DP, Weiner JL  Ethanol modulation of excitatory and Inhibitory synaptic transmission in rat and monkey dentate granule neurons  Alcohol Clin. Exp. Res. 2003; 27:1632-1639.

Floyd DW, D.P. Friedman, J.B. Daunais, P. J. Pierre, K. A. Grant, and B. A. McCool  “Long-term Ethanol Self-Administration by Cynomolgus Macaques Alters the Pharmacology and Expression of GABA(A) Receptors Expressed in Basolateral Amygdala”, J Pharmacol Exp Ther 2004; 311: 1071-1079.

Sullivan EV, Sable HJ, Strother WN, Friedman DP, Davenport A, Smith HT, Kraft RA, Wyatt C, Szeliga KT, Buchheimer NC, Daunias JB, Adalsteinsson E, Pfefferbaum A, Grant KA.  “Neuroimaging of rodent and primate models of alcoholism: Initial reports from the Integrative Neuroscience Initiative on alcoholism”  Alcohol Clin. Exp. Res.2005; 29:287-294.

Shively CA, Register TC, Friedman, DP, Morgan T, Thompson J, Lanier T. Social Stress -Associated Depression in Adult Female Cynomolgus Monkeys (Macaca fascicularis). Biological Psychology 2005;69:67-84.

Alexander GM, Carden WB, Mu J, Kurukulasuriya NC, McCool BA, Nordskog BK, Friedman DP, Daunais JB, Grant KA, Godwin DW. The native T-type calcium current in relay neurons of the primate thalamus. Neuroscience. 2006; 11:141:453-61.

Carden WB, Alexander GM, Friedman DP, Daunais JB, Grant KA, Mu J, Godwin DW. Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates. Brain Res. 2006; 1089:92-100. 

Shively CA, Friedman DP, Gage HD, Bounds MC, Brown-Proctor C, Blair JB, Henderson JA, Smith MA, Buchheimer N. Behavioral depression and positron emission tomography-determined serotonin 1A receptor binding potential in cynomolgus monkeys.  Arch Gen Psychiatry. 2006; Apr:396-403.

Hemby SE, O’connor JA, Acosta G, Floyd D, Anderson N, McCool BA, Friedman D, Grant KA.  Ethanol-induced regulation of GABA subunit mRNAs in prefrontal fields of cynomolgus monkeys. Alcohol Clin Exp Res. 2006; 30:1978-85.

Davenport A, Grant KA, Friedman DP Hippocampal GABA A Receptor Response to Chronic Ethanol Self-Administration in Monkeys J Pharmacol Exp Ther  (In review)